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KMID : 0369820090390010055
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 1 p.55 ~ p.58
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Efficacy of Hydrogel Patch in Wound Rat Model
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Oh Seung-Seok
Kim Hee-Sook
Shin Young-Hee
Kim Chul-Jun
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Abstract
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Sodium polyacrylate based hydrogel patch was prepared and its wound healing efficacy in comparison with control groups was evaluated in thermal burn wound (, 10 sec burn) and excision wound rat model. Cytotoxicity of gamma irradiated (25 kGy) hydrogel patch was investigated in human fibroblasts and showed no significant cytotoxicity. Wound closure rates (H50%) in hydrogel patch group and BAND- treated group were faster than that of control group (uncovered open wound). Hydrogel patch showed an enhancement in wound healing process.
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KEYWORD
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Hydrogel Patch, Thermal Burn Model, Excision Wound Rat Model, Wound Healing
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